Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite
Identifieur interne : 000523 ( Main/Exploration ); précédent : 000522; suivant : 000524Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite
Auteurs : Deepika Kannan [Inde] ; Nisha Yadav [Inde] ; Shakeel Ahmad [Inde] ; Pragya Namdev [Inde] ; Souvik Bhattacharjee [Inde] ; Bimlesh Lochab [Inde] ; Shailja Singh [Inde]Source :
- EBioMedicine [ 2352-3964 ] ; 2019.
Abstract
Artesunate the most potent antimalarial is widely used for the treatment of multidrug-resistant malaria. The antimalarial cytotoxicity of artesunate has been mainly attributed to its selective, irreversible and iron- radical-mediated damage of parasite biomolecules. In the present research, iron oxide nanoparticle fortified artesunate was tested in
Antimalarial efficacy of Iron oxide nanoparticle fortified artesunate was evaluated in wild type and artemisinin-resistant
The nanoparticle fortified artesunate was highly efficient in the 1/8th concentration of artesunate IC50 and led to retarded growth of
Surface coated iron-oxide nanoparticle fortified artesunate can be developed into a potent therapeutic agent towards multidrug-resistant and artemisinin-resistant malaria in humans.
This study is supported by the Centre for Study of Complex Malaria in India funded by the National Institute of Health, USA.
Url:
DOI: 10.1016/j.ebiom.2019.06.026
PubMed: 31255656
PubMed Central: 6642363
Affiliations:
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India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar</wicri:regionArea><wicri:noRegion>Gautam Buddha Nagar</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Shakeel" sort="Ahmad, Shakeel" uniqKey="Ahmad S" first="Shakeel" last="Ahmad">Shakeel Ahmad</name><affiliation wicri:level="1"><nlm:aff id="af0015">Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Namdev, Pragya" sort="Namdev, Pragya" uniqKey="Namdev P" first="Pragya" last="Namdev">Pragya Namdev</name><affiliation wicri:level="1"><nlm:aff id="af0015">Special Center for Molecular 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type="wicri:Area/Main/Exploration">000523</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite</title><author><name sortKey="Kannan, Deepika" sort="Kannan, Deepika" uniqKey="Kannan D" first="Deepika" last="Kannan">Deepika Kannan</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar</wicri:regionArea><wicri:noRegion>Gautam Buddha Nagar</wicri:noRegion></affiliation></author><author><name sortKey="Yadav, Nisha" sort="Yadav, Nisha" uniqKey="Yadav N" first="Nisha" last="Yadav">Nisha Yadav</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar</wicri:regionArea><wicri:noRegion>Gautam Buddha Nagar</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Shakeel" sort="Ahmad, Shakeel" uniqKey="Ahmad S" first="Shakeel" last="Ahmad">Shakeel Ahmad</name><affiliation wicri:level="1"><nlm:aff id="af0015">Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Namdev, Pragya" sort="Namdev, Pragya" uniqKey="Namdev P" first="Pragya" last="Namdev">Pragya Namdev</name><affiliation wicri:level="1"><nlm:aff id="af0015">Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Bhattacharjee, Souvik" sort="Bhattacharjee, Souvik" uniqKey="Bhattacharjee S" first="Souvik" last="Bhattacharjee">Souvik Bhattacharjee</name><affiliation wicri:level="1"><nlm:aff id="af0015">Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Lochab, Bimlesh" sort="Lochab, Bimlesh" uniqKey="Lochab B" first="Bimlesh" last="Lochab">Bimlesh Lochab</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar</wicri:regionArea><wicri:noRegion>Gautam Buddha Nagar</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Shailja" sort="Singh, Shailja" uniqKey="Singh S" first="Shailja" last="Singh">Shailja Singh</name><affiliation wicri:level="1"><nlm:aff id="af0015">Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Special Center for Molecular Medicine, Jawaharlal Nehru University, New Mehrauli Road, New Delhi</wicri:regionArea><wicri:noRegion>New Delhi</wicri:noRegion></affiliation></author></analytic><series><title level="j">EBioMedicine</title><idno type="eISSN">2352-3964</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Artesunate the most potent antimalarial is widely used for the treatment of multidrug-resistant malaria. The antimalarial cytotoxicity of artesunate has been mainly attributed to its selective, irreversible and iron- radical-mediated damage of parasite biomolecules. In the present research, iron oxide nanoparticle fortified artesunate was tested in <italic>P. falciparum</italic> and in an experimental malaria mouse model for enhancement in the selectivity and toxicity of artesunate towards parasite. Artesunate was fortified with nontoxic biocompatible surface modified iron oxide nanoparticle which is specially designed and synthesized for the sustained pH-dependent release of Fe<sup>2+</sup> within the parasitic food vacuole for enhanced ROS spurt.</p></sec><sec><title>Methods</title><p>Antimalarial efficacy of Iron oxide nanoparticle fortified artesunate was evaluated in wild type and artemisinin-resistant <italic>Plasmodium falciparum</italic> (R539T) grown in O + ve human blood and in <italic>Plasmodium berghei</italic> ANKA infected swiss albino mice. Internalization of nanoparticles, the pH-dependent release of Fe<sup>2+</sup>, production of reactive oxygen species and parasite biomolecule damage by iron oxide nanoparticle fortified artesunate was studied using various biochemical, biophysical, ultra-structural and fluorescence microscopy. For determining the efficacy of ATA-IONP+ART on resistant parasite ring survival assay was performed.</p></sec><sec><title>Results</title><p>The nanoparticle fortified artesunate was highly efficient in the 1/8th concentration of artesunate IC<sub>50</sub> and led to retarded growth of <italic>P. falciparum</italic> with significant damage to macromolecules mediated <italic>via</italic> enhanced ROS production. Similarly, preclinical <italic>In vivo</italic> studies also signified a radical reduction in parasitemia with ~8–10-fold reduced dosage of artesunate when fortified with iron oxide nanoparticles. Importantly, the ATA-IONP combination was efficacious against artemisinin-resistant parasites.</p></sec><sec><title>Interpretation</title><p>Surface coated iron-oxide nanoparticle fortified artesunate can be developed into a potent therapeutic agent towards multidrug-resistant and artemisinin-resistant malaria in humans.</p></sec><sec><title>Fund</title><p>This study is supported by the Centre for Study of Complex Malaria in India funded by the National Institute of Health, USA.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fauci, A S" uniqKey="Fauci A">A.S. Fauci</name></author><author><name sortKey="Morens, D M" uniqKey="Morens D">D.M. Morens</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Meshnick, S R" uniqKey="Meshnick S">S.R. Meshnick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, N J" uniqKey="White N">N.J. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, N J" uniqKey="White N">N.J. White</name></author><author><name sortKey="Pukrittayakamee, S" uniqKey="Pukrittayakamee S">S. Pukrittayakamee</name></author><author><name sortKey="Hien, T T" uniqKey="Hien T">T.T. Hien</name></author><author><name sortKey="Faiz, M A" uniqKey="Faiz M">M.A. Faiz</name></author><author><name sortKey="Mokuolu, O A" uniqKey="Mokuolu O">O.A. Mokuolu</name></author><author><name sortKey="Dondorp, A M" uniqKey="Dondorp A">A.M. Dondorp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dondorp, A M" uniqKey="Dondorp A">A.M. Dondorp</name></author><author><name sortKey="Nosten, F" uniqKey="Nosten F">F. Nosten</name></author><author><name sortKey="Yi, P" uniqKey="Yi P">P. Yi</name></author><author><name sortKey="Das, D" uniqKey="Das D">D. Das</name></author><author><name sortKey="Phyo, A P" uniqKey="Phyo A">A.P. Phyo</name></author><author><name sortKey="Tarning, J" uniqKey="Tarning J">J. Tarning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eastman, R T" uniqKey="Eastman R">R.T. Eastman</name></author><author><name sortKey="Fidock, D A" uniqKey="Fidock D">D.A. Fidock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enserink, M" uniqKey="Enserink M">M. Enserink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, N J" uniqKey="White N">N.J. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meshnick, S R" uniqKey="Meshnick S">S.R. Meshnick</name></author><author><name sortKey="Taylor, T E" uniqKey="Taylor T">T.E. Taylor</name></author><author><name sortKey="Kamchonwongpaisan, S" uniqKey="Kamchonwongpaisan S">S. Kamchonwongpaisan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phyo, A P" uniqKey="Phyo A">A.P. Phyo</name></author><author><name sortKey="Nkhoma, S" uniqKey="Nkhoma S">S. Nkhoma</name></author><author><name sortKey="Stepniewska, K" uniqKey="Stepniewska K">K. Stepniewska</name></author><author><name sortKey="Ashley, E A" uniqKey="Ashley E">E.A. Ashley</name></author><author><name sortKey="Nair, S" uniqKey="Nair S">S. Nair</name></author><author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R. McGready</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nosten, F" uniqKey="Nosten F">F. Nosten</name></author><author><name sortKey="White, N J" uniqKey="White N">N.J. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Straimer, J" uniqKey="Straimer J">J. Straimer</name></author><author><name sortKey="Gn Dig, N F" uniqKey="Gn Dig N">N.F. Gnädig</name></author><author><name sortKey="Witkowski, B" uniqKey="Witkowski B">B. Witkowski</name></author><author><name sortKey="Amaratunga, C" uniqKey="Amaratunga C">C. Amaratunga</name></author><author><name sortKey="Duru, V" uniqKey="Duru V">V. Duru</name></author><author><name sortKey="Ramadani, A P" uniqKey="Ramadani A">A.P. Ramadani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dwivedi, A" uniqKey="Dwivedi A">A. Dwivedi</name></author><author><name sortKey="Reynes, C" uniqKey="Reynes C">C. Reynes</name></author><author><name sortKey="Kuehn, A" uniqKey="Kuehn A">A. Kuehn</name></author><author><name sortKey="Roche, D B" uniqKey="Roche D">D.B. Roche</name></author><author><name sortKey="Khim, N" uniqKey="Khim N">N. Khim</name></author><author><name sortKey="Hebrard, M" uniqKey="Hebrard M">M. Hebrard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meshnick, S R" uniqKey="Meshnick S">S.R. Meshnick</name></author><author><name sortKey="Thomas, A" uniqKey="Thomas A">A. Thomas</name></author><author><name sortKey="Ranz, A" uniqKey="Ranz A">A. Ranz</name></author><author><name sortKey="Xu, C M" uniqKey="Xu C">C.M. Xu</name></author><author><name sortKey="Pan, H Z" uniqKey="Pan H">H.Z. Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stocks, P A" uniqKey="Stocks P">P.A. Stocks</name></author><author><name sortKey="Bray, P G" uniqKey="Bray P">P.G. Bray</name></author><author><name sortKey="Barton, V E" uniqKey="Barton V">V.E. Barton</name></author><author><name sortKey="Al Helal, M" uniqKey="Al Helal M">M. Al-Helal</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M. Jones</name></author><author><name sortKey="Araujo, N C" uniqKey="Araujo N">N.C. Araujo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pusic, K" uniqKey="Pusic K">K. Pusic</name></author><author><name sortKey="Aguilar, Z" uniqKey="Aguilar Z">Z. Aguilar</name></author><author><name sortKey="Mcloughlin, J" uniqKey="Mcloughlin J">J. McLoughlin</name></author><author><name sortKey="Kobuch, S" uniqKey="Kobuch S">S. Kobuch</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name></author><author><name sortKey="Tsang, M" uniqKey="Tsang M">M. Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuen, C" uniqKey="Yuen C">C. Yuen</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mebrahtu, T" uniqKey="Mebrahtu T">T. Mebrahtu</name></author><author><name sortKey="Stoltzfus, R J" uniqKey="Stoltzfus R">R.J. Stoltzfus</name></author><author><name sortKey="Chwaya, H M" uniqKey="Chwaya H">H.M. Chwaya</name></author><author><name sortKey="Jape, J K" uniqKey="Jape J">J.K. Jape</name></author><author><name sortKey="Savioli, L" uniqKey="Savioli L">L. Savioli</name></author><author><name sortKey="Montresor, A" uniqKey="Montresor A">A. Montresor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nwanyanwu, O C" uniqKey="Nwanyanwu O">O.C. Nwanyanwu</name></author><author><name sortKey="Ziba, C" uniqKey="Ziba C">C. Ziba</name></author><author><name sortKey="Kazembe, P N" uniqKey="Kazembe P">P.N. Kazembe</name></author><author><name sortKey="Gamadzi, G" uniqKey="Gamadzi G">G. Gamadzi</name></author><author><name sortKey="Gondwe, J" uniqKey="Gondwe J">J. Gondwe</name></author><author><name sortKey="Redd, S C" uniqKey="Redd S">S.C. Redd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verhoef, H" uniqKey="Verhoef H">H. Verhoef</name></author><author><name sortKey="West, C E" uniqKey="West C">C.E. West</name></author><author><name sortKey="Nzyuko, S M" uniqKey="Nzyuko S">S.M. Nzyuko</name></author><author><name sortKey="De Vogel, S" uniqKey="De Vogel S">S. de Vogel</name></author><author><name sortKey="Van Der Valk, R" uniqKey="Van Der Valk R">R. van der Valk</name></author><author><name sortKey="Wanga, M A" uniqKey="Wanga M">M.A. Wanga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sazawal, S" uniqKey="Sazawal S">S. Sazawal</name></author><author><name sortKey="Black, R E" uniqKey="Black R">R.E. Black</name></author><author><name sortKey="Ramsan, M" uniqKey="Ramsan M">M. Ramsan</name></author><author><name sortKey="Chwaya, H M" uniqKey="Chwaya H">H.M. Chwaya</name></author><author><name sortKey="Stoltzfus, R J" uniqKey="Stoltzfus R">R.J. Stoltzfus</name></author><author><name sortKey="Dutta, A" uniqKey="Dutta A">A. Dutta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholl, P F" uniqKey="Scholl P">P.F. Scholl</name></author><author><name sortKey="Tripathi, A K" uniqKey="Tripathi A">A.K. Tripathi</name></author><author><name sortKey="Sullivan, D J" uniqKey="Sullivan D">D.J. Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subramanian, S" uniqKey="Subramanian S">S. Subramanian</name></author><author><name sortKey="Hardt, M" uniqKey="Hardt M">M. Hardt</name></author><author><name sortKey="Choe, Y" uniqKey="Choe Y">Y. Choe</name></author><author><name sortKey="Niles, R K" uniqKey="Niles R">R.K. Niles</name></author><author><name sortKey="Johansen, E B" uniqKey="Johansen E">E.B. Johansen</name></author><author><name sortKey="Legac, J" uniqKey="Legac J">J. Legac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roy, C N" uniqKey="Roy C">C.N. Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, M A" uniqKey="Clark M">M.A. Clark</name></author><author><name sortKey="Goheen, M M" uniqKey="Goheen M">M.M. Goheen</name></author><author><name sortKey="Cerami, C" uniqKey="Cerami C">C. Cerami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bachmann, M F" uniqKey="Bachmann M">M.F. Bachmann</name></author><author><name sortKey="Jennings, G T" uniqKey="Jennings G">G.T. Jennings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, M" uniqKey="Lu M">M. Lu</name></author><author><name sortKey="Cohen, M H" uniqKey="Cohen M">M.H. Cohen</name></author><author><name sortKey="Rieves, D" uniqKey="Rieves D">D. Rieves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thu, M S" uniqKey="Thu M">M.S. Thu</name></author><author><name sortKey="Bryant, L H" uniqKey="Bryant L">L.H. Bryant</name></author><author><name sortKey="Coppola, T" uniqKey="Coppola T">T. Coppola</name></author><author><name sortKey="Jordan, E K" uniqKey="Jordan E">E.K. Jordan</name></author><author><name sortKey="Budde, M D" uniqKey="Budde M">M.D. Budde</name></author><author><name sortKey="Lewis, B K" uniqKey="Lewis B">B.K. Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kandasamy, G" uniqKey="Kandasamy G">G. Kandasamy</name></author><author><name sortKey="Surendran, S" uniqKey="Surendran S">S. Surendran</name></author><author><name sortKey="Chakrabarty, A" uniqKey="Chakrabarty A">A. Chakrabarty</name></author><author><name sortKey="Kale, S N" uniqKey="Kale S">S.N. Kale</name></author><author><name sortKey="Maity, D" uniqKey="Maity D">D. Maity</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trager, W" uniqKey="Trager W">W. Trager</name></author><author><name sortKey="Jensen, J B" uniqKey="Jensen J">J.B. Jensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Witkowski, B" uniqKey="Witkowski B">B. Witkowski</name></author><author><name sortKey="Amaratunga, C" uniqKey="Amaratunga C">C. Amaratunga</name></author><author><name sortKey="Khim, N" uniqKey="Khim N">N. Khim</name></author><author><name sortKey="Sreng, S" uniqKey="Sreng S">S. Sreng</name></author><author><name sortKey="Chim, P" uniqKey="Chim P">P. Chim</name></author><author><name sortKey="Kim, S" uniqKey="Kim S">S. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Worldwide Antimalarial Resistance Network" uniqKey="Worldwide Antimalarial Resistance Network">Worldwide Antimalarial Resistance Network</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mbengue, A" uniqKey="Mbengue A">A. Mbengue</name></author><author><name sortKey="Bhattacharjee, S" uniqKey="Bhattacharjee S">S. Bhattacharjee</name></author><author><name sortKey="Pandharkar, T" uniqKey="Pandharkar T">T. Pandharkar</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Estiu, G" uniqKey="Estiu G">G. Estiu</name></author><author><name sortKey="Stahelin, R V" uniqKey="Stahelin R">R.V. Stahelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gopalakrishnan, A M" uniqKey="Gopalakrishnan A">A.M. Gopalakrishnan</name></author><author><name sortKey="Kumar, N" uniqKey="Kumar N">N. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levine, R L" uniqKey="Levine R">R.L. Levine</name></author><author><name sortKey="Garland, D" uniqKey="Garland D">D. Garland</name></author><author><name sortKey="Oliver, C N" uniqKey="Oliver C">C.N. Oliver</name></author><author><name sortKey="Amici, A" uniqKey="Amici A">A. Amici</name></author><author><name sortKey="Climent, I" uniqKey="Climent I">I. Climent</name></author><author><name sortKey="Lenz, A G" uniqKey="Lenz A">A.G. Lenz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mesquita, C S" uniqKey="Mesquita C">C.S. Mesquita</name></author><author><name sortKey="Oliveira, R" uniqKey="Oliveira R">R. Oliveira</name></author><author><name sortKey="Bento, F" uniqKey="Bento F">F. Bento</name></author><author><name sortKey="Geraldo, D" uniqKey="Geraldo D">D. Geraldo</name></author><author><name sortKey="Rodrigues, J V" uniqKey="Rodrigues J">J.V. Rodrigues</name></author><author><name sortKey="Marcos, J C" uniqKey="Marcos J">J.C. Marcos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemmer, L" uniqKey="Clemmer L">L. Clemmer</name></author><author><name sortKey="Martins, Y C" uniqKey="Martins Y">Y.C. Martins</name></author><author><name sortKey="Zanini, G M" uniqKey="Zanini G">G.M. Zanini</name></author><author><name sortKey="Frangos, J A" uniqKey="Frangos J">J.A. Frangos</name></author><author><name sortKey="Carvalho, L J" uniqKey="Carvalho L">L.J. Carvalho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phenrat, T" uniqKey="Phenrat T">T. Phenrat</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Tilton, R D" uniqKey="Tilton R">R.D. Tilton</name></author><author><name sortKey="Lowry, G V" uniqKey="Lowry G">G.V. Lowry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monisha, M" uniqKey="Monisha M">M. Monisha</name></author><author><name sortKey="Yadav, N" uniqKey="Yadav N">N. Yadav</name></author><author><name sortKey="Srivastava, S B" uniqKey="Srivastava S">S.B. Srivastava</name></author><author><name sortKey="Singh, S P" uniqKey="Singh S">S.P. Singh</name></author><author><name sortKey="Lochab, B" uniqKey="Lochab B">B. Lochab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haynes, R K" uniqKey="Haynes R">R.K. Haynes</name></author><author><name sortKey="Chan, W C" uniqKey="Chan W">W.C. Chan</name></author><author><name sortKey="Lung, C M" uniqKey="Lung C">C.M. Lung</name></author><author><name sortKey="Uhlemann, A C" uniqKey="Uhlemann A">A.C. Uhlemann</name></author><author><name sortKey="Eckstein, U" uniqKey="Eckstein U">U. Eckstein</name></author><author><name sortKey="Taramelli, D" uniqKey="Taramelli D">D. Taramelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gopalakrishnan, A M" uniqKey="Gopalakrishnan A">A.M. Gopalakrishnan</name></author><author><name sortKey="Kumar, N" uniqKey="Kumar N">N. Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X. Guo</name></author><author><name sortKey="Arnold, K" uniqKey="Arnold K">K. Arnold</name></author><author><name sortKey="Jian, H" uniqKey="Jian H">H. Jian</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L. Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cumming, J N" uniqKey="Cumming J">J.N. Cumming</name></author><author><name sortKey="Ploypradith, P" uniqKey="Ploypradith P">P. Ploypradith</name></author><author><name sortKey="Posner, G H" uniqKey="Posner G">G.H. Posner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tornvall, U" uniqKey="Tornvall U">U. Törnvall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romero, M R" uniqKey="Romero M">M.R. Romero</name></author><author><name sortKey="Efferth, T" uniqKey="Efferth T">T. Efferth</name></author><author><name sortKey="Serrano, M A" uniqKey="Serrano M">M.A. Serrano</name></author><author><name sortKey="Casta O, B" uniqKey="Casta O B">B. Castaño</name></author><author><name sortKey="Macias, R I" uniqKey="Macias R">R.I. Macias</name></author><author><name sortKey="Briz, O" uniqKey="Briz O">O. Briz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Utzinger, J" uniqKey="Utzinger J">J. Utzinger</name></author><author><name sortKey="Shuhua, X" uniqKey="Shuhua X">X. Shuhua</name></author><author><name sortKey="N Goran, E K" uniqKey="N Goran E">E.K. N'Goran</name></author><author><name sortKey="Bergquist, R" uniqKey="Bergquist R">R. Bergquist</name></author><author><name sortKey="Tanner, M" uniqKey="Tanner M">M. Tanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efferth, T" uniqKey="Efferth T">T. Efferth</name></author><author><name sortKey="Dunstan, H" uniqKey="Dunstan H">H. Dunstan</name></author><author><name sortKey="Sauerbrey, A" uniqKey="Sauerbrey A">A. Sauerbrey</name></author><author><name sortKey="Miyachi, H" uniqKey="Miyachi H">H. Miyachi</name></author><author><name sortKey="Chitambar, C R" uniqKey="Chitambar C">C.R. Chitambar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, H" uniqKey="Lai H">H. Lai</name></author><author><name sortKey="Singh, N P" uniqKey="Singh N">N.P. Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name></author><author><name sortKey="Park, H" uniqKey="Park H">H. Park</name></author><author><name sortKey="Greever, R" uniqKey="Greever R">R. Greever</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Isacchi, B" uniqKey="Isacchi B">B. Isacchi</name></author><author><name sortKey="Arrigucci, S" uniqKey="Arrigucci S">S. Arrigucci</name></author><author><name sortKey="Marca, G L" uniqKey="Marca G">G.L. Marca</name></author><author><name sortKey="Bergonzi, M C" uniqKey="Bergonzi M">M.C. Bergonzi</name></author><author><name sortKey="Vannucchi, M G" uniqKey="Vannucchi M">M.G. Vannucchi</name></author><author><name sortKey="Novelli, A" uniqKey="Novelli A">A. Novelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, J W" uniqKey="Wong J">J.W. Wong</name></author><author><name sortKey="Yuen, K H" uniqKey="Yuen K">K.H. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, N P" uniqKey="Singh N">N.P. Singh</name></author><author><name sortKey="Lai, H C" uniqKey="Lai H">H.C. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klonis, N" uniqKey="Klonis N">N. Klonis</name></author><author><name sortKey="Crespo Ortiz, M P" uniqKey="Crespo Ortiz M">M.P. Crespo-Ortiz</name></author><author><name sortKey="Bottova, I" uniqKey="Bottova I">I. Bottova</name></author><author><name sortKey="Abu Bakar, N" uniqKey="Abu Bakar N">N. Abu-Bakar</name></author><author><name sortKey="Kenny, S" uniqKey="Kenny S">S. Kenny</name></author><author><name sortKey="Rosenthal, P J" uniqKey="Rosenthal P">P.J. Rosenthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zanganeh, S" uniqKey="Zanganeh S">S. Zanganeh</name></author><author><name sortKey="Hutter, G" uniqKey="Hutter G">G. Hutter</name></author><author><name sortKey="Spitler, R" uniqKey="Spitler R">R. Spitler</name></author><author><name sortKey="Lenkov, O" uniqKey="Lenkov O">O. Lenkov</name></author><author><name sortKey="Mahmoudi, M" uniqKey="Mahmoudi M">M. Mahmoudi</name></author><author><name sortKey="Shaw, A" uniqKey="Shaw A">A. Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoshyar, N" uniqKey="Hoshyar N">N. Hoshyar</name></author><author><name sortKey="Gray, S" uniqKey="Gray S">S. Gray</name></author><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author><author><name sortKey="Bao, G" uniqKey="Bao G">G. Bao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodyer, I D" uniqKey="Goodyer I">I.D. Goodyer</name></author><author><name sortKey="Pouvelle, B" uniqKey="Pouvelle B">B. Pouvelle</name></author><author><name sortKey="Schneider, T G" uniqKey="Schneider T">T.G. Schneider</name></author><author><name sortKey="Trelka, D P" uniqKey="Trelka D">D.P. Trelka</name></author><author><name sortKey="Taraschi, T F" uniqKey="Taraschi T">T.F. Taraschi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olliaro, P L" uniqKey="Olliaro P">P.L. Olliaro</name></author><author><name sortKey="Goldberg, D E" uniqKey="Goldberg D">D.E. Goldberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radfar, A" uniqKey="Radfar A">A. Radfar</name></author><author><name sortKey="Diez, A" uniqKey="Diez A">A. Diez</name></author><author><name sortKey="Bautista, J M" uniqKey="Bautista J">J.M. Bautista</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Zhang, C J" uniqKey="Zhang C">C.J. Zhang</name></author><author><name sortKey="Chia, W N" uniqKey="Chia W">W.N. Chia</name></author><author><name sortKey="Loh, C C" uniqKey="Loh C">C.C. Loh</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Lee, Y M" uniqKey="Lee Y">Y.M. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ismail, H M" uniqKey="Ismail H">H.M. Ismail</name></author><author><name sortKey="Barton, V E" uniqKey="Barton V">V.E. Barton</name></author><author><name sortKey="Panchana, M" uniqKey="Panchana M">M. Panchana</name></author><author><name sortKey="Charoensutthivarakul, S" uniqKey="Charoensutthivarakul S">S. Charoensutthivarakul</name></author><author><name sortKey="Biagini, G A" uniqKey="Biagini G">G.A. Biagini</name></author><author><name sortKey="Ward, S A" uniqKey="Ward S">S.A. Ward</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Kannan, Deepika" sort="Kannan, Deepika" uniqKey="Kannan D" first="Deepika" last="Kannan">Deepika Kannan</name></noRegion><name sortKey="Ahmad, Shakeel" sort="Ahmad, Shakeel" uniqKey="Ahmad S" first="Shakeel" last="Ahmad">Shakeel Ahmad</name><name sortKey="Bhattacharjee, Souvik" sort="Bhattacharjee, Souvik" uniqKey="Bhattacharjee S" first="Souvik" last="Bhattacharjee">Souvik Bhattacharjee</name><name sortKey="Lochab, Bimlesh" sort="Lochab, Bimlesh" uniqKey="Lochab B" first="Bimlesh" last="Lochab">Bimlesh Lochab</name><name sortKey="Namdev, Pragya" sort="Namdev, Pragya" uniqKey="Namdev P" first="Pragya" last="Namdev">Pragya Namdev</name><name sortKey="Singh, Shailja" sort="Singh, Shailja" uniqKey="Singh S" first="Shailja" last="Singh">Shailja Singh</name><name sortKey="Yadav, Nisha" sort="Yadav, Nisha" uniqKey="Yadav N" first="Nisha" last="Yadav">Nisha Yadav</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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